A study comparing four different conventional treatments for neuropathic pain in cryptogenic sensory polyneuropathy (CSPN), a common neuropathy seen in middle aged to older adults. The study will compare in open-label fashion the following commonly used agents for neuropathic pain: pregabalin, duloxetine, nortriptyline and mexiletine.

There is very little hard data as to which drugs are most effective at relieving the pain of peripheral neuropathy. The federal government is funding a study through the PCORI program that is designed by a highly respected group of physicians along with patient community input to measure the relative effectiveness of currently approved medications.

Anyone over age 18 with the above types of painful neuropathy

Pain at a certain level arising from CSPN (see above) or small fiber painful neuropathy that is not due to diabetes or other identified cause. Patients have to be off neuropathic pain agents for one week but can receive other analgesics during this time period if needed.

$50 per clinic visit or phone visit related to the study.

Gil I. Wolfe, MD Nicholas J. Silvestri, MD

Name: Kara Patrick
Phone: 716-859-7510
Email: kpatrick@buffalo.edu