In our previous studies we have found that insulin reduces the inflammation in the blood in overweight individuals. We know that insulin is used as a treatment to reduce blood sugars in diabetics. We also know that insulin infusion is safe and reduces inflammatory mediators in obese. But it has not yet known whether insulin reduces inflammation in the blood vessels in normal subjects, thin diabetics or overweight diabetics. Therefore we want to investigate whether insulin can cause reduction of inflammatory markers in the blood vessels in these individuals